Functional group compatibility in an amide bond cleavage reaction with hydrazine was evaluated for 26 functional Play Dough groups in the functional group evaluation (FGE) kit.Accurate and rapid evaluation of the compatibility of functional groups, such as nitrogen-containing heterocycles important in drug discovery research, will enhance the appli

Abstract Major Depressive Disorder, or depression, has been extensively linked to dysregulated HPA axis function, chronic inflammation and cardiovascular diseases.While the former two have been studied in depth, the mechanistic connection between depression and cardiovascular disease is unclear.As major mediators of vascular homeostasis, Play Dough

Adaptive lenses offer axial scanning without mechanical translation and thus are promising to replace mechanical-movement-based axial scanning in microscopy.The scan is accomplished by sweeping the applied voltage.However, the relation between the applied voltage and the resulting axial focus position is not unambiguous.Adaptive lenses suffer from

Background: Seizure duration has long been measured as a potential marker of ECT treatment efficacy, with concern that short seizures may be clinically ineffective.Relatively small studies have documented a trend towards shorter seizures during acute course ECT, but data from large cohorts would help provide normative data on seizure duration chang

As the core of blockchain technology, the consensus algorithm plays an important role in determining the security, data consistency, and efficiency of blockchain systems.The existing mainstream consensus algorithm is experiencing difficulties satisfying the needs of efficiency, security, and decentralization in real-world scenarios.This paper propo